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The e-cigarette aerosol that users breathe from the device and exhale can contain harmful and potentially harmful substances, including nicotine ultrafine particles that can be inhaled deep into the lungs flavorings such as diacetyl, a chemical linked to a serious lung disease volatile organic compounds cancer-causing chemicals heavy metals such as nickel, tin, and lead

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They haven’t been studied in a rigorous manner.” Rizzo also notes that studies on e-cigarettes are especially challenging due to difficulties in making direct comparisons